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Recombinant Proteins

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208816 Crystallin, alpha A, Recombinant, Human (CRYA1, HSPB4)

Alpha crystallins are composed of two gene products; alpha-A and alpha-B, for acidic and basic, respectively. Alpha crystallins can be induced by heat shock and are members of the small heat shock protein (sHSP also known as the HSP20). They act as molecular chaperones and hold them in large soluble aggregates. These heterogeneous aggregates consist of 30-40 subunits; the alpha-A and alpha-B subunits have a 3:1 ratio, respectively. Two additional functions of a-crystallins are an autokinase activity and participation in the intracellular architecture. The expression of alpha-A is preferentially restricted to the lens cell.

 

Source

Recombinant protein corresponding to human Crystallin Alpha A, a single, non-glycosylated polypeptide chain containing 173aa, expressed in E. coli.

 

Molecular Weight

~19.9kD

 

AA Sequence

MDVTIQHPWF KRTLGPFYPS RLFDQFFGEG LFEYDLLPFL SSTISPYYRQ SLFRTVLDSGISEVRSDRDK FVIFLDVKHF SPEDLTVKVQ DDFVEIHGKH NERQDDHGYI SREFHRRYRLPSNVDQSALS CSLSADGMLT FCGPKIQTGL DATHAERAIP VSREEKPTSA PSS

 

Storage and Stability

May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.

 

Source

E. coli

 

Purity

~95% (RP-HPLC, SDS-PAGE)

 

Concentration

~1mg/ml

 

Form

Supplied as a liquid in 20mM Tris-HCl, pH 7.5, 50mM sodium chloride, 1mM EDTA.

 

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Specifications

Grade

Highly Purified

Molecular Weight

19.9

EU Commodity Code

30021019

Shipping Temp

Blue Ice

Storage Temp

-20°C

Size

20ug

Price: $397.00
Quantity:
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